I'm maintaining an ASP.NET Webforms 4.5 application for a few months and frankly i'm fed up with server controls. So i switched to pure HTML and Javascript for front end, when creating new content (or fixing the old, assuming there was enough time). Almost (for reusability reasons) all new requests to the server are done via ajax calls.
I'm happy, designers are happy, coworkers prefer it and the client seems to like the new ajax functionality very much.
Are there any drawbacks i should be aware of while doing so?