This is quite dependent on the game's terms of use (they might forbid those tools).
A random sampling says:
Blizzard says:
You agree that you will not, under any circumstances:
[...]
use cheats, automation software (bots), hacks, mods or any other unauthorized third-party software designed to modify the World of Warcraft experience;
EA says:
You may violate the Terms of Service if, as determined by EA in its sole discretion, you: [...]
- Promote, encourage or take part in any activity involving hacking, cracking, phishing, taking advantage of exploits or cheats and/or distribution of counterfeit software and/or virtual currency/items.
Zynga says:
CHEATING AND HACKING - You agree that you will not, under any circumstances:
[...]
d. Use cheats, exploits, automation software, bots, hacks, mods or any unauthorized third party software designed to modify or interfere with the Service or any Zynga game experience;
Even if the game's terms of use don't allow those tools, there's the subjective aspect: some gamers will consider those tools unethical and look down on anybody who uses them.
As stated on a comment, while in singleplayer games they'd be OK, in multiplayer games they will most likely seen as cheating.