On PC motherboards you commonly see 0.100" headers used for USB 2.0 connections, often for a cable running to ports on the front of the PC. Here's an example.
https://www.digikey.com/en/products/detail/tripp-lite/U024-003-5P-PM/7243242
USB cables are supposed to have a differential impedance of 90 ohms +/- 15%. Maybe those headers just happen to be close to 90 ohms, but I doubt it. Even if they are, terminating the wires to the headers requires untwisting the D+/D- twisted pair for some short length, and I'm sure that is a significant deviation from the impedance requirement.
Does this ever lead to signal integrity problems, or is it not an issue for USB 2.0 as long as the rest of the path is well designed?