Imagine a typical PCB that's small, 6" per side. There's a clocked circuit on it. Making a 1kHz circuit is pretty easy. Making a 2kHz circuit isn't any harder, and neither is a 3kHz circuit. But at some point, this changes, and now the circuit gets flaky. Maybe it becomes an antenna. Maybe a chip is too slow.
Do I just add up the time required by the data sheets for the longest chain-o-logic and add some slack?
Are there any guidelines on when the side effects of a higher clockspeed starts mattering?
Assume that more Hz are better than fewer, of course :-D