...taught to envision electricity flow similar to water flow, flowing downhill from high potential to low potential...
At the voltages typical of electronics circuits that we might encounter (i.e., tens of volts, even the low hundreds of volts) it's better to envision electricity as flowing in pipes. Electrical current is mostly carried by electrons, which are strongly attracted to the protons in atomic nuclei. You can't rip very many electrons off of a piece of wire before they get lonely and want to jump back.
All analogies break down at some point, and the "electric current is like water in a pipe" analogy breaks down at the point where water will drip out of a pipe -- electrons won't, in general, drip off of a wire.
...but lightning doesn't flow in a loop...
I just did some research on this (strictly Wikipedia, because I'm lazy), and I can't find a reference that directly contradicts this. However, it must. Why? Because electrostatic attraction is hugely more powerful than gravity. So something must equalize the charge between the cloud and the ground after a lightning strike, or there's some mechanism that carries charge from the cloud to the ground before the strike.
The lighting strike may not flow in a loop -- but it's the consequence of a capacitor getting charged up, and that capacitor will discharge, eventually.